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Antibody related to Heavy metal detoxification and Oxidative stress

Anti Metallothionein monoclonal antibody

Background

Metallothinein(MT), a cysteine-rich(30%), metal-binding protein, exists in most tissues and is easily induced by many stimuli. It’s multifunction roles in the body have been proposed such as a chelator to harmful heavy metals and excessive essential metals, a scavenger to various radicals and active oxygen species, and a regulator in the cell proliferation process.

This product consists of protein G purified mouse monoclonal antibody against rabbit MT-2 and can be used for immunoblotting. This antibody reacts with rabbit MT-1,2, human MT-1, mouse MT-1 and rat MT-1.

Package Size 100μg(100μL/vial)
Format
Buffer
Mouse monoclonal antibody 1.0mg/mL
2% Block Ace as a stabilizer, containing 0.1% proclin as a bacteriostat
Storage Store below  20°C.
Once thawed, store at 4°C. Repeated freeze-thaw cycles should be avoided.
Purification ethod The splenic lymphocytes from BALB/c mouse, immunized with rabbit metallothionein-2, were fused to myeloma P3U1 cells. The cell line (1A12) with positive reaction was grown in ascitic fluid of BALB/c mouse, from which the antibody was purified by Protein G affinity chromatography.
Working dilution for immunoblotting: 0.01μg/mL
Specificity This antibody reacts with rabbit MT-1,2, human MT-1, mouse MT-1 and rat MT-1

Product List

Product Name Cat# Quantity Price

Anti Metallothionein

KAL-KA009 100UG

¥ 45,000
$ 600
€ 450

Anti Metallothionein

KAL-KA009-01 100UG

¥ 70,000
$ 934
€ 700

References
  • Yasutake A, et al.(1998) : Induction by Mercury Compounds of Brain Metallothionein in Rats:Hgo Exposure Induces Long-lived Brain Metallothionein.
    Arch Toxcol.vol.72,No4, 187-191
  • Mullins JE, et al.(1998) : Immunohistochemical Detection of Metallothionein in Liver,Duodenum and Kidney after Dietary Copper-Overload in Rats.
    Histol Histopathol.vol.13,No.3, 627-633
  • Kikuchi Y, et al,(1993) : Induction of Metallothionein in a Human Astrocytoma Cell Line by Interleukin-1 and heavy Metals .
    FFBS Lett.,vol.317,No1-2, 22-26
  • M.Nordberg.(1998): Metallothionein: historical review and state of knowledge. Talanta 46(2), 243-254
  • Akintola DF, et al.(1995) : Development of an enzyme-linked immunosorbent assay for human metallothionein-1 in plasma and urine.
    J.Lab.126(2) 119-127