The thyroid stimulating hormone receptor (TSHR) ,also known as LGR3, is a member of the leucine-rich repeat-containing G protein-coupled receptor (LGR) family. TSHR is expressed mainly in thyroid follicular cells and is activated by TSH, which regulates the growth and function of thyroid follicular cells.
Graves’ disease is a common type of autoimmune thyroid disease, in that the generation of autoantibodies against the TSHR causes continuous stimulation of the thyroid gland hyperthyroidism. It has been demonstrated that TSHR are present on the surface of melanoma cells, through which TSH promotes melanoma growth. It has been also showed that TSH/TSHR regulates transcription of the TNFα gene, osteoclast formation and osteoporosis arise from TSHR deficiency. This antibody is specific to TSHR and will be useful for research on autoimmune thyroid disease, osteoporosis, tumor such as melanoma.
|Source||Serum Free Medium|
|Cross Reactivity||Not yet tested in other species.|
|Contents(Volume)||50 μg(200 μL/vial)|
|Buffer||PBS [containing 2 % Block Ace as a stabilizer, 0.1 %Proclin as a bacteriostat]|
|Storage||Store below –20 °C. Once thawed, store at 4 °C. Repeated freeze-thaw cycles should be avoided.|
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2. Ellerhorst JA. et al.: Human melanoma cells express functional receptors for thyroid-stimulating hormone. Endocr Relat Cancer. 2006 Dec;13(4):1269-77.
3. Hase H. et al.: TNFalpha mediates the skeletal effects of thyroid-stimulating hormone. Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12849-54. Epub 2006 Aug 14.
4. Szkudlinski MW. et al.: Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships. Physiol Rev. 2002 Apr;82(2):473-502. Review.
Anti Thyroid Stimulating Hormone Receptor / TSHR