RAGE (receptor for AGEs, advanced glycation end products) is an around 35 kDa multiligand receptor classified as an immunoglobulin
superfamily cell surface molecule. RAGE is found in endothelium, smooth muscle cells, cardiac myocytes, neural tissue, and mononuclear
cells and two major truncated forms of RAGE have been also identified (N-terminally truncated, C- terminally truncated). RAGE acts as
a couter-receptor for not only AGEs, but also high-mobility group box1 (HMGB1), S100/calgranulins, and amyloid-β peptides. Intracellular
signaling pathways induced by RAGE include the activation of Cdc42/Rac, MAP kinase, NF-κB. The C-terminally truncated soluble form of
RAGE can bind ligands including AGEs and antagonize RAGE signaling in vitro and in vivo.
RAGE plays important role for immflammation, diabetes, diabetic complications such as nephropathy, vascular injury and Alzheimer’s disease. Several clinical studiese have demonstrated that the strong association of RAGE expression with malignant potential of various cancers. It has been showed that engagement of RAGE by HMGB1 plays an important role in regulating the tumor formation, growth, metastasis. It is also suggested that glyceraldehyde- and glycolaldehyde-derived AGEs may be significantly involved in the growth and invasion of melanoma through interactions with RAGE.
This antibody is specific to RAGE and will be useful to research for cancer, chromic diseases associated with aging and diabetic complications.