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For research on cancer, chromic diseases associated with aging and diabetic complications

Anti Human RAGE Monoclonal Antibody

Background

RAGE (receptor for AGEs, advanced glycation end products) is an around 35 kDa multiligand receptor classified as an immunoglobulin superfamily cell surface molecule. RAGE is found in endothelium, smooth muscle cells, cardiac myocytes, neural tissue, and mononuclear cells and two major truncated forms of RAGE have been also identified (N-terminally truncated, C- terminally truncated). RAGE acts as a couter-receptor for not only AGEs, but also high-mobility group box1 (HMGB1), S100/calgranulins, and amyloid-β peptides. Intracellular signaling pathways induced by RAGE include the activation of Cdc42/Rac, MAP kinase, NF-κB. The C-terminally truncated soluble form of RAGE can bind ligands including AGEs and antagonize RAGE signaling in vitro and in vivo.
RAGE plays important role for immflammation, diabetes, diabetic complications such as nephropathy, vascular injury and Alzheimer’s disease. Several clinical studiese have demonstrated that the strong association of RAGE expression with malignant potential of various cancers. It has been showed that engagement of RAGE by HMGB1 plays an important role in regulating the tumor formation, growth, metastasis. It is also suggested that glyceraldehyde- and glycolaldehyde-derived AGEs may be significantly involved in the growth and invasion of melanoma through interactions with RAGE.
This antibody is specific to RAGE and will be useful to research for cancer, chromic diseases associated with aging and diabetic complications.


 AGEs Antibody Flyer [PDF]
 AGEs Antibody Flyer (print file) [PDF]
 

Application

WB 0.1 µg/mL
IHC Not tested
ICC 1.0 µg/mL
ELISA 0.01 µg/mL
FCM 1.0 µg/mL
Neutralization Not tested
IP Not tested

This product is generated from GANP mice

Product List

Product Name Cat# Quantity Price

Anti RAGE

KAL-KG134 50UG

¥ 55,000
$ 734
€ 550

Anti RAGE

KAL-KH039 100UG

¥ 49,000
$ 654
€ 490

References
  • Taguchi A,et al., Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases.Nature. 2000 May 18;405(6784):354-60. PMID: 10830965
  • Yonekura H,et al., Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury. Biochem J. 2003 Mar 15;370(Pt 3):1097-109. PMID: 12495433
  • Abe R,et al., Regulation of human melanoma growth and metastasis by AGE-AGE receptor interactions. J Invest Dermatol. 2004 Feb;122(2):461-7. PMID: 15009731
  • Riuzzi F,et al., The amphoterin (HMGB1)/receptor for advanced glycation end products (RAGE) pair modulates myoblast proliferation, apoptosis, adhesiveness, migration, and invasiveness. Functional inactivation of RAGE in L6 myoblasts results in tumor formation in vivo. J Biol Chem. 2006 Mar 24;281(12):8242-53. Epub 2006 Jan 9. PMID: 16407300
  • Koyama H,et al., RAGE and soluble RAGE: potential therapeutic targets for cardiovascular diseases. Mol Med. 2007 Nov-Dec;13(11-12):625-35. PMID: 17932553