Pentraxins are a superfamily of conserved proteins characterized by the pentraxin domain. CRP and SAP are recognized as classical short pentraxins, whereas Pentraxin3(PTX3) belongs to the long pentraxins. CRP and SAP are induced in the liver in response to IL-6. In contrast, PTX3 is produced by a variety of tissues and cells, such as vascular endothelial cells, macrophages, and neutrophils, predominantly in response to proinflammatory signals (bacterial products, IL-1, andTNF).
This antibody specifically recognizes human PTX3.
In order to obtain the best results, optimal working dilutions should be determined by each individual user.
Western Blot : 1 ug/mL
ELISA : Decide by use
Immunohistochemistry : Decide by use
1. Imamura M, et al. Cell Immunol.2007; 248(2):86-94.
2. Savchenko A, et al. J Pathol. 2008 May;215(1):48-55.