LGR4, also known as GPR48, is a member of the leucine-rich repeat (LRR)-containing G protein-coupled receptor (LGR) family. LGR4 is composed of the extracellular domain containing 18 LRRs, the seven-transmembrane region. LGR4 is widely expressed in ovary, testis, adrenal, placenta, thymus, spinal cord, and thyroid in human.
The LGR4 knockout mice show intrauterine growth retardation, remarkable decreases in the kidney and liver weights, suggesting that LGR4 plays important role for embryonic growth, especially for kidney and liver development. A study, by use of the LGR4 hypomorphic mutant mice, showed that the homozygous male is infertile, showing morphologic abnormality in both the testes and the epididymides. Moreover, it has been demonstrated that up-regulation of LGR4 enhances carcinoma cell invasiveness and metastasis.
This antibody is specific to LGR4 and will be useful for research on embryonic growth, postnatal development, tumor invasiveness and metastasis.
|Source||Serum Free Medium|
|Cross Reactivity||Not yet tested in other species.|
|Contents(Volume)||50 μg(200 μL/vial)|
|Buffer||PBS [containing 2 % Block Ace as a stabilizer, 0.1 %Proclin as a bacteriostat]|
|Storage||Store below 20 °C. Once thawed, store at 4 °C. Repeated freeze-thaw cycles should be avoided.|
1. Hoshii T. et al.: LGR4 Regulates the Postnatal Development and Integrity of Male Reproductive Tracts in Mice. Biol Reprod. 2007 Feb;76(2):303-13. Epub 2006 Nov 1.
2. Gao Y. et al.: Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis. Cancer Res.2006 Dec 15;66(24):11623-31.
3. Mazerbourg S. et al.: Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality. Mol Endocrinol. 2004 Sep;18(9):2241-54. Epub 2004 Jun 10.
4. Hsu SY. et al.: Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region. Mol Endocrinol. 1998 Dec;12(12):1830-45.
Anti Leucine-rich repeat-containing G protein-coupled receptor 4 / LGR4