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For the study of identify the mechanism AD and the research for novel therapeutic approach.

Anti Human Humanin Polyclonal Antibody

Background

Alzheimer disease (AD) is characterized as neurodegenerative disease showing impairment of cognitive function, death of neuronal cells, numerous numbers of senile plaques and tangle of neurofilaments. Humanin, HN, is novel 24- residue peptide which protects neuronal cell death . HN shows neuroprotective activity to the cell damage not only with known three familial AD gene such as APP, PS1, and PS2 but also with Abeta peptide. HN is a secretary peptide and exerts its protective function from the outside of the cell.
This antibody is useful not only to the study of identify the mechanism AD but also to the research for novel therapeutic approach.

Package Size 25g (100L/vial)
Format Rabbit polyclonal antibody 0.25mg/mL
Buffer Block Ace as a stabilizer, containing 0.1% Proclin as a bacteriostat
Storage Below 20C°
Once thawed, store at 4C° Repeated freeze-thaw cycles should be avoided.
Purification method This antibody was purified from rabbit serum by affinity chromatography.
Working dilution For western blotting ; 0.1~0.2 g/mL

Western blotting

Sample:Humanin peptide
Preparation of antibodies and instruction
Dr.Nishimoto I. and Dr. Niikura T. at Department of Pharmacology, Keio University School of Mediceine.

<Reference>
1. Hashimoto Y,et al. :Proc. Natl. Acad. Sci. USA ,2001,98,6336-41
2. Hashimoto Y, et al. :Biochem. Biophys. Res. Commun. 2001,283,460-468
3. Hashimoto Y, et al. :J.Neurosci.2001,21,9235-9245
4. Tajima H,et al.:Neurosci. Lett. 2002,324:227-31

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