HSD3B2 is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The HSD3B2 enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Expressed in adrenal gland, testis and ovary.
Involvement in disease
Adrenal hyperplasia 2
Belongs to the 3-beta-HSD family.
|Sample: COS7 cells transfected with HA-tagged HSD3B2/pEZ or others
Lane 1; COS7 cells transfected with empty vector pEZ
Lane 2; COS7 cells transfected with HA-tagged HSD3B1/pEZ
Lane 3; COS7 cells transfected with HA-tagged HSD3B2/pEZ
Provided from Dr. Doi M.
Graduate School of Pharmaceutical Sciences, Kyoto University
To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.