G5PR was cloned as novel protein which could bind to Germinal center Associated DNA Primase(GANP). GANP is involved in important events that regulate DNA replication in activated germinal centre B cells. G5PR is homologous to known regulatory B’’ subunits of PP2A, and the G5PR protein is associated with PP5 and PP2A, suggesting that G5PR is a GANP-associated PPase component. G5PR contributes to the regulation of the phosphorylation state of the chromatin-bound or nonbound form of MCM3 (minichromosome replication molecule 3) in vivo. So that, G5PR might regulate MCM3/GANP complex phosphorylation state during cell cycle progression.
This antibody is very useful for immunoprecipitation and westernblotting.
Working dilution for immunoprecipitation : 2 μg
Working dilution for western blotting : 1〜5 μg/mL
Preparation of antibodies and instruction
|Package Size||25μg (100μL / vial)|
|Format||Rabbit polyclonal antibody 0.25mg/mL|
|Buffer||Block Ace as a stabilizer, containing 0.1% Proclin as a bacteriostat|
|Purification method||This antibody was purified from rabbit serum by affinity chromatography.|
1. Genes Cells 2002 Aug;7(8):821-34
To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.