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regulatory T cells can be sorted alive to investigate the functions

Anti FR4 (Folate Receptor 4) Antibody / Treg-marker

Background

Regulatory T cells are important for immune tolerance and perform adverse immunoreaction, compared with activated T cells. The discrimination between the regulatory T cells and the activated T cells is very important for immunology research. Although Foxp3 is well-known as an intracellular marker of regulatory T cell, it is inevitable that the regulatory T cell cannot be maintained alive after the reaction with Foxp3.
Folate receptor 4 is newly found to be a highly expressed surface marker of the regulatory T cells. The anti mouse- regulatory T cell antibody can react specifically with the surface marker. When the antibody is used for regulatory T cells instead of Foxp3, the cell can be sorted alive to investigate the functions.

Experiment example

Clone (TH6)
Application: Immunoprecipitation, Flow Cytometry




Flow Cytometry Analysis

Detection of cell membrane mouse folate receptor 4(TH6) in spleen of mouse.
Cells were stained by using PE-conjugated anti-mouse CD25, APC-conjugated anti-mouse CD4 mouse, and the folate receptor4 antibody & anti-rat IgG FITC conjugated.
Flow cytometry was performed on a FACS Vantage SETM.


Clone (12A5)
Application: Western Blot, Immunoprecipitation, Flow Cytometry




Flow Cytometry Analysis

Detection of cell membrane mouse folate receptor 4(12A5) in spleen of mouse.
Cells were stained by using PE-conjugated anti-mouse CD25, APC-conjugated anti-mouse CD4 mouse, and the folate receptor4 antibody & anti-rat IgG FITC conjugated.
Flow cytometry was performed on a FACS Vantage SETM.

Product List

Product Name Cat# Quantity Price

Anti Folate Receptor 4(Treg-marker)

REC-RCAB010M-F 100UL

¥ 29,500
$ 394
€ 295

Anti Folate Receptor 4(Treg-marker)

REC-RCAB010M-FB 100UL

¥ 29,500
$ 394
€ 295

Anti Folate Receptor 4(Treg-marker)

REC-RCAB010M-FF 100UL

¥ 29,500
$ 394
€ 295

Anti Folate Receptor 4(Treg-marker)

REC-RCAB011M-F 100UL

¥ 29,500
$ 394
€ 295

Anti Folate Receptor 4(Treg-marker)

REC-RCAB011M-FB 100UL

¥ 29,500
$ 394
€ 295

Anti Folate Receptor 4(Treg-marker)

REC-RCAB011M-FF 100UL

¥ 29,500
$ 394
€ 295

References
  • T Ymaguchi,K Hirota et al.:Control of Immune Responses by Antigen-Specific Regulatory T Cells Expressing the Folate Receptor. Immunity 27,1-5, July 2007

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.