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Anti-TFIID subunit1 / TAF1 / CCG1 / KAT4

Background

Function: TAFIID subunit1 (1,872 aa, 213 kDa) is the largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.

Involvement in diseases: Dystonia 3, torsion, X-linked (DYT3) [MIM:314250]: A X-linked dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT3 is characterized by severe progressive torsion dystonia followed by parkinsonism. It has a well-defined pathology of extensive neuronal loss and mosaic gliosis in the striatum (caudate nucleus and putamen) which appears to resemble that in Huntington disease.

Application

 

Fig.1 Identification of TAF1 protein in whole cell extract of HeLa cells by western blotting using anti-TAF1 antibody.
Lane 1; Size marker proteins (kDa)
Lane 2; HeLa cell whole extract (10 µg) Arrow indicates the position of TAF1 protein band

Product List

Product Name Cat# Quantity Price

Anti TFIID subunit1

BAM-70-457EX 100UL

¥ 34,500
$ 460
€ 345

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.