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Amyotrophic Lateral Sclerosis (ALS)-Related Products

Background

Go to Antibodies for Neurodegenerative Disease Research page
 

Amyotrophic lateral sclerosis (ALS), also referred to as motor neurone disease (MND), Charcot disease, and, in the United States, Lou Gehrig's disease, has been increasing in the current aging society and is becoming a serious social problem. It is characterised by muscle spasticity, rapidly progressive weakness due to muscle atrophy, and difficulty in speaking (dysarthria), swallowing, and breathing. ALS is the most common of the five motor neuron diseases. Cosmo Bio provides a wide variety of antibodies and reagents for ALS-related research.


Immunohistochemistry of TDP-43 lesions. PAb “pS409/410-1” recognize neuronal cytoplasmic inclusions (NCIs) in dentate gyrus of FLTD-U. Note: PAb pS409/410-1 sometimes stained ghost tangles and dot-like structures (granulovacuolar degeneration) in the hippocampal and other regions of brains with AD or other related diseases. For this reason, we recommend pS409/410-2 or mAb pS409/410 for immunohisochemistry of human tissues

Immunohistochemistry of TDP-43 lesions. NCIs in dentate gyrus of FTLD-U are specifically stained. Bars 100 lm. MAb pS409/410 stains ubiquitin-positive inclusions in FTLD-U and ALS without nuclear staining. This does not stain ghost tangles and granulovacuolar degeneration in AD or other related diseases by immunohistochemistry.

 

 

Immunoblot analyses with pAb pS409/410-1, Perdicted molecular weight: Phosphorylated full-length TDP-43 at 45 kDa, - 25 kDa fragments and smearing substances in FTLD-U, ALS and other related disorders

 

 

 

   
Immunohistochemistry of TDP-43 lesions. PAb “pS409/410-2” recognize neuronal cytoplasmic inclusions (NCIs) in dentate gyrus of FLTD-U and stains ubiquitin-positive inclusions in FTLD-U and ALS without nuclear staining. This does not stain ghost tangles and granulovacuolar degeneration in AD or other related diseases.

Immunoblot analyses with pAb pS409 Perdicted molecular weight: Phosphorylated full-length TDP-43 at 45 kDa, non-phosphorylated TDP-43 at 43 kDa, - 25 kDa fragments and smearing substances in FTLD-U, ALS.

 

 

Immunoblot analyses with pAb pS409/410-2, Perdicted molecular weight: Phosphorylated full-length TDP-43 at 45 kDa, unphosphorlated TDP-43 at 43 kDa, -25 kDa fragments and smearing substances in FTLD-U and ALS.

Product List

Product Name Cat# Quantity Price

Anti 4R-tau

CAC-TIP-4RT-P01 50UL

¥ 50,000
$ 667
€ 500

Anti C9orf72 (Poly-GA)

CAC-TIP-C9-P01 50UL

¥ 40,000
$ 534
€ 400

Anti C9orf72 (Poly-GR)

CAC-TIP-C9-P02 50UL

¥ 40,000
$ 534
€ 400

Anti C9orf72 (Poly-GP)

CAC-TIP-C9-P03 50UL

¥ 40,000
$ 534
€ 400

Anti TDP-43, phospho Ser409/410

CAC-TIP-PTD-M01 50UL

¥ 50,000
$ 667
€ 500

Anti TDP-43, phospho Ser409/410-2

CAC-TIP-PTD-P02 100UL

¥ 50,000
$ 667
€ 500

Anti TDP-43, phospho Ser409

CAC-TIP-PTD-P03 100UL

¥ 50,000
$ 667
€ 500

Anti TDP-43, phospho Ser410

CAC-TIP-PTD-P04 100UL

¥ 50,000
$ 667
€ 500

Anti TDP-43, phospho Ser403/404

CAC-TIP-PTD-P05 100UL

¥ 50,000
$ 667
€ 500

Anti TDP-43 (3-12)

CAC-TIP-TD-P07 100UL

¥ 50,000
$ 667
€ 500

Anti TDP-43 (405-414)

CAC-TIP-TD-P09 100UL

¥ 50,000
$ 667
€ 500

Anti (ALPHA) Synuclein (1-10)

CAC-TIP-SN-P01 50UL

¥ 32,000
$ 534
€ 400

Anti (ALPHA) Synuclein (11-20)

CAC-TIP-SN-P02 50UL

¥ 32,000
$ 534
€ 400

Anti (ALPHA) Synuclein (21-30)

CAC-TIP-SN-P03 50UL

¥ 32,000
$ 534
€ 400

Anti (ALPHA) Synuclein (31-40)

CAC-TIP-SN-P04 50UL

¥ 32,000
$ 534
€ 400

Anti (ALPHA) Synuclein (41-50)

CAC-TIP-SN-P05 50UL

¥ 32,000
$ 534
€ 400

Anti (ALPHA) Synuclein (51-60)

CAC-TIP-SN-P06 50UL

¥ 32,000
$ 534
€ 400

Anti (ALPHA) Synuclein (61-70)

CAC-TIP-SN-P07 50UL

¥ 32,000
$ 534
€ 400

Anti (ALPHA) Synuclein (75-91)

CAC-TIP-SN-P08 50UL

¥ 32,000
$ 534
€ 400

Anti (ALPHA) Synuclein (131-140)

CAC-TIP-SN-P09 50UL

¥ 32,000
$ 534
€ 400

Anti (ALPHA) Synuclein (9 antibodies set)

CAC-TIP-SN-SET 9*10UL

¥ 72,000
$ 1200
€ 900

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.