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Software for 4D cell simulation


True Cell Simulations Inc. offers our customers advanced services with our A-Cell software and long-term experience in 4D cell simulation. 4D cell simulation is essential for revealing mechanisms of a cell. A-Cell provides an easiest environment for pathway and 4D cell simulation, and is a powerful tool both for molecular cell biologists and researchers of drug discovery.

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A-Cell Simulation Service

Service overview
We provide a service of A-Cell simulation for basic research and drug discovery both in academia and in pharmaceutical companies. We construct an A-Cell model according to your research, run simulations, and compare them with your experimental results. Simulation results are returned together with an A-Cell model. This enables you for further investigation by running simulations with modified model and/or parameter values. Thus, you can make in silico confirmation of your experimental results, and know potential problems in early stages of drug discovery. This can be an NDA-based service on request.

Information you provide
1) Purpose (To validate ....; To make a forecast on ....; Or any others.)
2) Pathway diagram (detailed, abstracted, or none)
3) Brief description of experiments and available data type (image, stimulus-response, time courses, electrophoresis, and etc.)

Results we provide
1) Simulation results
2) Comparison between your experimental and our simulation results
3) A-Cell model file


A research paper on cell biology by using simulation was published as early as 1961. Since then, computer simulation has been recognized as a tool for cell biology, but the community was small. Since 2005, however, there has been an explosive increase in the number of papers, and more than 3,000 papers are published a year in 2014. In addition, many papers are being published in collaboration with wet experiments. However, there still exist questions and uncertainties when you try to introduce or collaborate with simulation study. The most fundamental question is what we can get by cell simulation that cannot be gotten by wet experiments. To answer these questions, we have been conducting cell simulation studies for 30 years showing that cell simulation is a powerful tool to make predictions. Thus, we can reach a conclusion that is not reached readily by wet experiments. To acquire this advantage by cell simulation in your wet experiments, we support researches both in private company and in educational and research institutes by our long-term experience and simulation software A-Cell.

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