This Offer starts from December 1st, 2016 to February 28th, 2017
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The major types of DNA damage induced by solar UV radiation are cyclobutane pyrimidine dimers (CPDs), and (6-4) photoproducts (6-4PPs), which are formed between adjacent pyrimidine nucleotides on the same DNA strand. These helix-distorting DNA lesions are repaired exclusively by a nucleotide excision repair system in humans.
Our High Sensitivity Cyclobutane Pyrimidine Dimers (CPDs) ELISA Kit is the only commercially available ELISA utilizing anti-CPD clone TDM-2 and has been optimized for high sensitivity detection of CPDs in DNA purified from cultured cells or from skin epidermis. Another Kit; High Sensitivity (6-4)photoproducts (6-4PPs) ELISA Kit is the only commercially available ELISA utilizing anti-6-4PPs clone 64M-2 and has been optimized for
high sensitivity detection of 6-4PPs in DNA purified from cultured cells or from skin epidermis.
This ELISA detects CPDs or 6-4PPs from dipyrimidines in all DNA sequence contexts (i.e., TT, TC, CT and CC). Thus, the availability and convenience of this ELISA Kit will contribute to further understanding molecular mechanisms involved in cellular responses to UV radiation and DNA damage with applications across many research fields including cancer research, photobiology, dermatology, ophthalmology, immunology, and cosmetics science.
To better study molecular events surrounding UV-induced DNA damage and repair, Mori et al. previously developed and characterized monoclonal antibody (mAb) specific for CPDs and mAb specific for 6-4PPs (1) while Matsunaga et al. developed and characterized mAb specific for DewarPPs (2). Three of these antibodies (CPDs: clone TDM-2; 6-4PPs: clone 64M-2; DewarPPs: clone DEM-1) continue to be cited frequently in the literature, often for use in ELISA by a recommended procedure.
|Description||Cat. No.||Size||List Price||Discount||Campaign Price|
|High Sensitivity 6-4PP/ (6-4) photoproduct ELISA kit||CSR-NM-MA-K002||1 KIT (96 TESTS)||¥100,000||20%||¥80,000|
|High Sensitivity 6-4PP/ (6-4) photoproduct ELISA kit Ver.2||CSR-NM-MA-K004||1 KIT (96 TESTS)||¥100,000||20%||¥80,000|
|High Sensitivity CPD ELISA kit Ver.2||CSR-NM-MA-K003||1 KIT (96 TESTS)||¥100,000||20%||¥80,000|
|PROTAMINE SULFATE COATED ELISA PLATE 96 x 5||CSR-NM-MA-P002||1*5 PLATE||¥9,500||20%||¥7,600|
|PROTAMINE SULFATE COATED ELISA PLATE 96 x 10||CSR-NM-MA-P003||1*10 PLATE||¥18,000||20%||¥14,400|
|UVC-irradiated DNA samples||CSR-NM-MA-R010||5*10 UG||¥30,000||20%||¥24,000|